Downstream Processing Market Share was valued at USD 21.5 billion in 2022 and is projected to grow from USD 24.95 Billion in 2023 to USD 61.09 billion by 2030, exhibiting a compound annual growth rate (CAGR) of 16.09% during the forecast period (2023 - 2030).

Downstream processing refers to the series of operations required to derive pure and homogeneous protein products from biological materials such as cells, tissue culture fluid, or plant tissues. There is a high demand for the end products extracted by downstream processing, owing to the increasing applicationsin biopharmaceutical products. Thus, the downstream processing market is anticipated to observe significant growth during the forecast period.

Many market players are dominating the global downstream processing market. The prominent players are involved in strategic agreements,new product launches developments,joint ventures, partnerships, collaborations, mergers acquisitions, geographic expansionto sustaintheir market positions.For instance, in March 2021, Thermo Fisher Scientific, Inc. (US) announced that more than USD 600 million would be invested to expand its bioprocessing production capabilities through 2022 to meet short-term demands related to COVID-19 as well as long-term efforts to improve new vaccines and biologics for other conditions.

Key Players

Some of the key players in the global downstream processing market are Thermo Fisher Scientific Inc. (US), Sartorius Stedim Biotech S.A. (France), Merck Millipore (Germany), Danaher Corporation (US), 3M Company (US), Boehringer Ingelheim (Germany), Lonza Group AG (Switzerland), Eppendorf AG (Switzerland), Corning Incorporated (US), and Asahi Kasei Corporation (Japan).

Segmentation

The global downstream processing market outlook has been segmented into technique, product, application, and end user.

By technique, the market has been segregated into cell disruption, solid-liquid separation, clarification/concentration, downstream purification techniques, and formulation. The purification techniques segment is further sub-segmented into ion exchange, affinity exchange, hydrophobic interaction, size exclusion chromatography, and others. The purification techniques segment held a significant share of the market in 2020, as it isone of the vital steps in downstream processing and has high product differentiation.

Based on the product, the global downstream processing market has been classified as chromatography columns resins, filters, membrane adsorbers, and others. The chromatography columns resinsis one of the most widely used product andwasestimated to bethe largest segment in 2020.

Based on application, the downstream processing market is segmented into antibiotic production, hormone production, antibodies production, vaccine production, and others. Antibiotic productionis one of the vital applications owing to increasing infectious diseases. Furthermore, the ongoing pandemic has created a huge demand for vaccine production globally which further supports the growth of the market.

Based on the end user, the downstream processing market is segmented into biopharmaceutical manufacturers, contract manufacturing organizations, and others. The biopharmaceutical manufacturers segment held the largest market share in 2020 due to increased RD activities and production of biologics at a largescale, along with the rapidly growing biopharmaceutical industry.

Regional Analysis

By region, North America is anticipated to dominate the global downstream processing market, owing to well-established research organizations involved in research activities, the presence of a high number of contract manufacturing organizations (CMOs), and the presence of a largenumber of pharmaceutical and biopharmaceutical companies. Moreover, the rise in RD investments by public and private players in the healthcare sectorfurther drives the market growth.

On the other hand, the European downstream processing market is driven by rising RD expenditure by biopharmaceutical companies, increasing investments in the RD sector, and the presence of key market players. For instance, in November 2019, Thermo Fisher Scientific, Inc. (US) announced that it is investing nearly USD 24 million in its Scotland site to expand global bioproduction capabilities with additional large-volume liquid manufacturing capacity for cell culture media.

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