What is the best medication for excessive daytime sleepiness?

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Different drugs may treat excessive daytime sleepiness (EDS) depending on the reason. For narcolepsy and shift work sleep disorder, modafinil (Modalert 20 is a common wakefulness aid. It boosts alertness and reduces tiredness by changing brain neurotransmitters. When modafinil isn't working, amphetamines or methylphenidate are used for EDS. Armodafinil (Nuvigil) has a longer half-life. For obstructive sleep apnea, CPAP treatment may be needed.

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